Bhattacharya Lab Member - Arye (Arik) Harel

image of Arik Harel
Arye (Arik) Harel
Agricultural Research Center (ARO) - Volcani Center
Bet-Dagan, 50250 Israel
  Email: harelarik[at]



  • Studying evolution of Oxidoreductases (EC1).
  • Understanding the role of redox reactions in Biogeochemical cycles.


Post Doctoral training (November 2010-December 2014)

Study the evolution of Oxidoreductases (EC1). Prof. Debashish Bhattacharya & Prof. Paul Falkowski. Department of Ecology, Evolution, and Natural Resources. Institute of Marine and Coastal Science. Rutgers, New Jersy, USA.

Post Doctoral training (July 2007-2010)
Developing the GeneCards* Inferred Functionality Score (GIFtS). Prof. Doron Lancet. July 2007-2010. Weizmann Institute of Science, The Department of Molecular Genetics, Rehovot.

Studies towards a degree in computers science (2007-2010)
System programming and advanced Java programming, databases systems and data structures, algorithms, structured programming and C, Unix/Linux operating systems, various topics in mathematics such as set theory, combinatory and logic.

A workshop for next generation sequencing (2009)
Wet-lab and data analysis utilizing software for mapping, analysis of gene expression, genomic annotations, and functional annotations.

PhD degree (2001 2006)
Involvement of Ser/Thr phosphatases associated with MAPK and PKA activities in sclerotial development of Sclerotinia sclerotiorum. Prof. Yarden Oded. Faculty of Agriculture and Food and Environmental Quality Science, Rehovot, Hebrew University of Jerusalem.

M.Sc. Agr. (1999 -2000) Summa cum laude
Use of transcriptional profiling for the identification of Neurospora crassa genes whose expression is altered in the presence of Cantharidin. Prof. Yarden Oded. Faculty of Agriculture and Food and Environmental Quality Science, Rehovot, Hebrew University of Jerusalem.

Research Assistant (1998)
Genetics and Breeding of tomato using DNA markers. Prof. Jossi Hillel. Hebrew University of Jerusalem, Faculty of Agriculture and Food and Environmental Quality Science, Rehovot.

B.Sc. Agr (1995 -1997)
Biochemistry and food technology . Faculty of Agriculture and Food and Environmental Quality Science, Rehovot Hebrew University of Jerusalem.


Harel A, Bromberg Y, Falkowski PG, Bhattacharya D. (2014). The evolutionary history of redox metal-binding domains across the tree of life. Proc Natl Acad Sci USA: vol. 111 no. 19, 70427047.

Kim JD, Senn S, Harel A, Jelen BI, Falkowski PG. Discovering the electronic circuit diagram of life: structural relationships among transition metal binding sites in oxidoreductases.
Philos Trans R Soc Lond B Biol Sci. 2013 Jun 10;368(1622):20120257.

Harel A., Falkowski P., Bromberg Y. (2012). TrAnsFuSE refines the search for protein function: oxidoreductases. Integr Biol (Camb) Apr 5.

Marilyn Safran, Irina Dalah, Justin Alexander, Arye Harel, Gil Stelzer, Tsippi Iny-Stein, Michael Shmoish, Naomi Rosen, Iris Bahir, Alexandra Madi, Emily Brewster, Scott Weisman, Yaron Golan and Doron Lancet (2010). GeneCards Version 3: the human gene integrator. Database: baq020.

Harel, A. Inger, Aron. Strichman-Almashanu, L. Safran, M. and Lancet, D. (2009). GIFtS: Annotation Landscape Analysis with GeneCards. Bioinformatics. BMC Bioinformatics 10:348

Stelzer G., Inger A., Olender T., Iny-Stein T., Dalah I., Harel A., Safran M., Lancet D. (2009). GeneDecks: paralog hunting and gene-set distillation with GeneCards annotation. OMICS 13(6)

Erental, A., Harel, A. and Yarden, O. (2007). Type 2A phosphoprotein phosphatase is required for asexual development and pathogenesis of Sclerotinia sclerotiorum. Mol. Plant-Microbe Interact. 20:944-954

Harel, A. Bercovich, S. Yarden, O. (2006) Calcineurin is required for sclerotial development and pathogenicity of Sclerotinia sclerotiorum in an oxalic acid independent manner. Plant-Microb Interact. 19:682-93.

Harel, A. Gorovits, R. Yarden, O. (2005) Changes in protein kinase A activity accompany sclerotial development in Sclerotinia sclerotiorum. Phytopathology 95: 397-404.

Chen, C. Harel, A. Gorovoits, R. Yarden, O. Dickman, M. B. (2004) MAPK regulation of sclerotial development in Sclerotinia sclerotiorum is linked with pH and cAMP sensing. Mol. Plant-Microb Interact. 17:404-413.

Last updated: March 27, 2014